The ability to conduct genomic analysis in the Cloud has altered the course of NGS adoption, enabling labs of all sizes and disciplines to integrate NGS into their operations regardless of resources. With the availability of analysis solutions on the Cloud, smaller labs that were previously unable to integrate NGS due to hefty onsite investment costs can now conduct genomic analysis using only their computers, broadening the accessibility of genomics on a global scale.
Last year, we brought our industry leading DRAGEN Bio-IT Platform into the Cloud via Amazon Web Services (AWS)’ EC2 F1 Instances, which are compute instances built on Xilinx’ UltraScale Plus Field Programmable Gate Arrays (FPGA). Utilizing these instance types, we are able to deliver our ultra-rapid, highly accurate analysis pipelines through a number of third-party Cloud platforms, including DNAnexus.
DNAnexus was the first Cloud platform to offer DRAGEN, and since then, DRAGEN on DNAnexus has been utilized by laboratories spanning all industries and global regions. In this blog, we explore the ins and outs of DRAGEN on the DNAnexus Platform at-length.
DNAnexus provides a global network for sharing and managing genomic data and tools to accelerate genomics, and is optimized to address the challenges of security, scalability and collaboration for organizations that are pursuing genomic-based approaches to health in the clinic and the lab. DRAGEN on DNAnexus provides a harmonious, highly secure access point for users to leverage DRAGEN on the Cloud, offering a seamless integration of DRAGEN’s highly optimized algorithms into the secure and scalable DNAnexus Platform.
DRAGEN on DNAnexus offers the fastest iteration of DRAGEN on the Cloud. Leveraging upload and download streaming of raw data and results from/to S3 cloud storage, DRAGEN on DNAnexus completes a run in approximately 1 hour and 30 minutes for a whole human genome at 30x coverage, vastly outpacing competing pipelines on the platform.
Figure 1 data extracted from independent benchmarks conducted by DNAnexus. Read the full results here.
DNAnexus is currently the only online platform offering Edico Genome’s enhanced DRAGEN Germilne V2+ Pipeline. Integrating enhanced algorithms for improved false positive rates and better sensitivity, Germline V2+ is DRAGEN’s most advanced pipeline. DNAnexus recently put the improved DRAGEN V2+ algorithm to the test in its benchmarking study. The full results can be viewed here.
Security & Compliance:
Data security is not a nice-to-have when it comes to working with genomic data – it’s essential. With DRAGEN on DNAnexus, customers have best-in-class security in the cloud. Platform features include two-factor authentication, end-to-end encryption, need-based network access control, 24/7 security monitoring and updates, and audit and access logging.
Furthermore, DNAnexus claims the industry’s most comprehensive security and privacy framework with ISO 27001, HIPPA CLIA, CAP, and GCP compliance. The extra layers of security and compliance provided through the DNAnexus Platform prove an ideal solution for government, clinical and additional laboratories seeking air-tight data security.
DRAGEN on DNAnexus makes it easy to collaborate with team members, whether you are working together across hallways or international borders. Researchers can use DNAnexus as a central hub to share data, tools, and analytical processing resources for streamlined collaboration.
Ease of Use:
DRAGEN was designed with ease-of-use in-mind, and when integrated with DNAnexus, it becomes the ultimate point and click, fully automated system. DNAnexus’ simple GUI interface makes it easy for users from all backgrounds and experience-levels to launch and run DRAGEN instantaneously. The platform is designed to be intuitive to all users, requiring little setup.
1. To launch, users can simply select the DRAGEN Pipeline they wish to leverage
2. Chose the desired project
3. Select input files for your project
4. Monitor your running job
5. View the output of the run when it is done
To learn more about DRAGEN on the DNAnexus Platform, email firstname.lastname@example.org with the subject “DRAGEN On DNAnexus,” or visit https://platform.dnanexus.com/apps?name=DRAGEN