The NHGRI, which signed a four-year contract with Edico Genome, was established to carry out the role of the National Institute of Health (NIH) in the International Human Genome Project (HGP). The institute is dedicated to the development of resources and technologies that accelerate genomic research and its application to human health.
The NCI purchased DRAGEN to provide operational and technical support for the Frederick National Laboratory for Cancer Research, which supports drug discovery and development for the NCI and the National Institute of Allergy and Infectious Diseases (NIAID), respectively. Additionally, the lab spearheads the RAS Initiative, a national undertaking that seeks to understand the mechanism of the mutant protein and create therapeutic agents.
“As an industry, we must each continue to take an active role in forwarding this important work to put an end to cancer,” said Pieter van Rooyen, Ph.D., chief executive officer of Edico Genome. “We designed DRAGEN to enable institutes such as the NHGRI and NCI to stay ahead of the big data bottleneck and expedite their timeframes for bringing vital research to light. With DRAGEN’s industry leading speed and high accuracy, labs can focus their time and money on what matters most – bringing personalized medicine into the mainstream.”
DRAGEN’s Somatic Pipeline is comprised of Edico Genome’s advanced Mapper/Aligner combined with its Tumor and Tumor/Normal Variant Caller algorithms. The Somatic pipeline is designed to detect smaller allele frequencies and distinguish between tumor frequencies and noise variations, enabling accurate analysis and variant detection.
Edico Genome’s DRAGEN platform is built on a reconfigurable Field Programable Gate Array (FPGA), enabling massively accelerated secondary analysis of genomic data. By implementing algorithms as logic circuits which can be massively parallelized, DRAGEN is able to deliver best-in-class performance, reducing the time needed to sequence a whole genome at 30x coverage from 20 to 30 hours using traditional technologies, such as BWA-GATK, to approximately 20 minutes.
DRAGEN is available onsite, in the cloud via Amazon Web Services (AWS) or as a hybrid cloud solution. To date, DRAGEN customers have processed more than 17 petabytes of data using the platform.