GATK Best Practices Workflow on DRAGEN
The GATK Best Practices Pipeline is an accelerated implementation of the open-sourced GATK 4.0 Haplotype Variant Caller from the Broad Institute on the DRAGEN platform.
Accelerated and Cost-Effective
The DRAGEN GATK Best Practices Pipeline for germline SNPs and INDELs utilizes the ultra-rapid analysis speeds of DRAGEN to accelerate version 3.7* of the GATK-HC Variant Caller. Harnessing the industry-leading processing power of DRAGEN, the DRAGEN GATK Best Practices Pipeline reduces the time required to analyze a whole genome from FASTQ to VCF at 30x coverage to ~22 minutes. The reduced compute time directly translates into significant cost savings both onsite and in the cloud without compromising accuracy or sensitivity.
Edico Genome’s DRAGEN GATK Best Practices Pipeline is built on GATK 4.0 made backward compatible to V3.7
GATK Best Practices on DRAGEN
GATK Best Practices describes the key principles for processing and analyzing raw reads from a sequencing instrument to produce a filtered variant callset suitable for downstream analyses. GATK Best Practices breaks the workflow into two required analysis phases and one optional phase that describes ways to handle or fine-tune the output VCF file.
Comprehensive Platform for Genomic Data Analysis and Storage
The GATK Best Practices Workflow on DRAGEN integrates into the larger DRAGEN ecosystem, a comprehensive platform for analyzing, re-analyzing, storing, and archiving genomic data. The highly flexible DRAGEN Platform allows users to effortlessly set up and manage highly complex workflows. It can be used onsite, in the cloud, or as a seamless hybrid cloud that includes an easy-to-use Web Portal and Workflow Management System. The Hybrid Cloud configuration provides users with the flexibility to scale up to the cloud during times of high capacity and return to onsite analysis when demand decreases.